In addition to common acrylic/methacrylic and styrenic main block polymers [24], poly(oxanorbornene)s [25], polyurethanes [134] and polycarbonates [135] with DA-clickable side groups have been employed in graft polymer synthesis. Eur Polym J 66:282–289, Acik G, Sey E, Tasdelen MA (2018) Polypropylene-based graft copolymers via CuAAC click chemistry. Adapted from [95] with permission. Growing the arms directly from a polymeric core was implemented by Wang et al. J Polym Sci Part A Polym Chem 47:1485–1498, Durmaz H, Dag A, Erdogan E, Demirel AL, Hizal G, Tunca U (2010) Multiarm star block and multiarm star mixed-block copolymers via azide-alkyne click reaction. %PDF-1.4 %���� Aust J Chem 60:400–404, He X, Liang L, Wang K, Lin S, Yan D, Zhang Y (2009) A new synthetic approach to asymmetric amphiphilic ABA′ block copolymers by ATRP and click reactions. Links which take you out of Abbott worldwide websites are not under the control of Abbott, and Abbott is not responsible for the contents of any such site or any further links from such site. Frick Lab and closer to the facilities for physics, molecular biology, Copyright © 2013 by The Royal Society of Chemistry. Google Scholar, Oz Y, Arslan M, Gevrek TN, Sanyal R, Sanyal A (2016) Modular fabrication of polymer brush coated magnetic nanoparticles: engineering the interface for targeted cellular imaging. Energy-efficient, highly reflective roof coatings made from acrylics, urethanes, silicones, and styrene … Synthesis of functional macrocycles via thio-bromo and thiol–ene reactions. In the design and construction of new homes, schools, offices and other buildings, architects rely on the products of chemistry to help maximize performance, energy efficiency and durability. J Polym Sci Part A Polym Chem 50:2025–2097, Laurent BA, Grayson SM (2011) Synthesis of cyclic dendronized polymers via divergent “graft- from” and convergent click “graft-to” routes: preparation of modular toroidal macromolecules. J Polym Sci Part A Polym Chem 44:1667–1675, Dag A, Durmaz H, Tunca U, Hizal G (2009) Multiarm star block copolymers via Diels–Alder click reaction. This highly efficient click reaction allows buildup of branched polymers from thiol or alkyne functional small molecules or macromolecules [194]. The ARCHITECT c4000 clinical chemistry analyzer demonstrates high-quality testing results and rapid STAT turnaround time. In case of click-propagating chain growing of two different functional blocks, multiblock hyperbranched copolymers could be achieved (Fig. Oftentimes, click chemistry methodologies accompany with aforementioned polymerization methods in post-polymerization functionalization or conjugation reactions [159]. The approach included the first attachment of azide groups at side chains and subsequent grafting conjugation with alkyne functional polymers. J Polym Sci Part A Polym Chem 46:7757–7772, Yang L, Zhou H, Shi G, Wang Y, Pan CY (2008) Synthesis of ABCD 4-miktoarm star polymers by combination of RAFT, ROP, and “click chemistry”. Macromol Rapid Commun 29:1016–1051, Binder WH, Sachsenhofer R (2008) “Click” chemistry in polymer and material science: an update. They can work on individual buildings or on large redevelopment schemes, and can be responsible for the design of the surrounding landscape and spaces. Highly efficient, orthogonal and robust click reactions possess ample opportunities in synthesis of complex macromolecules especially when they combined with various polymerization methods and post-polymerization modification techniques. Block copolymers constitute an essential part of complex polymer architectures and in their diversities, they are potential building blocks in formation of self-assembly driven nano- and micro-structures [48, 49]. Working closely with clients and users,they make sure that projected designs match requirements and are functional, safe and economical. "We wanted to choose architects who could which will likely be across from the entry point of the chemistry to consolidate a "science neighborhood" that also would incorporate For the efficient building of complex macromolecules via click reactions, properly functionalized polymers are key components in which special design is required to successful installation of ‘clickable’ reactive groups on polymer end groups or side chains. Polym Chem 7:1603–1611, Iskin B, Yilmaz G, Yagci Y (2011) ABC type miktoarm star copolymers through combination of controlled polymerization techniques with thiol-ene and azide-alkyne click reactions. J Polym Sci Part A Polym Chem 51:2252–2259, Hsu YI, Masutani K, Yamaoka T, Kimura Y (2015) Strengthening of hydrogels made from enantiomeric block copolymers of polylactide (PLA) and poly(ethylene glycol) (PEG) by the chain extending Diels–Alder reaction at the hydrophilic PEG terminals. According to Robert Cava, professor and chair of chemistry, J Polym Sci Part A Polym Chem 47:178–187, Altinbasak I, Sanyal R, Sanyal A (2016) Best of both worlds: Diels–Alder chemistry towards fabrication of redox-responsive degradable hydrogels for protein release. This approach provides fine tuning of material properties by altering the grafting density via controlled attachment of reactive side chain groups. Core-crosslinked star polymers are fundamental macromolecular constructs where they find important biomedical applications. RSC Adv 4:57834–57841, Arslan M, Gevrek TN, Lyskawa J, Szunerits S, Boukherroub R, Sanyal R, Woisel P, Sanyal A (2014) Bioinspired anchorable thiol-reactive polymers: synthesis and applications toward surface functionalization of magnetic nanoparticles. /?php brickthemewp_top_bar_l('Header'); ?>, American Institute of Architects’ (AIA) 2015 Convention, Understanding Chemistry in Building and Construction, Diisocyanates: A Family of Versatile Building Blocks Important to Our Everyday Lives, We All Have a Role to Play in What Our Future Looks Like – And So Does the Business of Chemistry. The ARCHITECT c4000 enhances laboratory productivity and provides users high confidence in clinical results. Adv Mater Interfaces 2:1500135, Article  0000078944 00000 n Hopkins will collaborate with Payette Associates, a nationally renowned Example is the concrete used, when specifying a certain type of concrete. In order to prevent the participation of the acetylenic units into polymerization, the alkyne functional initiators are usually protected with suitable protecting groups prior to the ATRP process [58, 59]; though there are examples that implement ATRP using initiators bearing unprotected alkyne functionalities [60,61,62]. not visible from the exterior but forms the heart and soul of the PubMed  By considering the synthetic aspects, the examples in design and synthesis of reactive polymers and further click coupling into higher macromolecular structures have been reviewed. Versatile click reactions have found wide applications in attachment of functional polymers onto side chains of complementary functional polymers. The group reported the highly efficient HDA cycloaddition conjugation of RAFT dithioester groups with macromolecules containing reactive cyclopentadiene or 2,4-hexadiene-terminated end caps (Fig.